CAN PRENATAL EXPOSURE TO PESTICIDES UNLEASH THE AUTISTIC SPECTRUM DISORDER?
AbstractAutism spectrum disorder (ASD) is characterized by impaired neurological development and difficulties in social relationships. The etiology of ASD is multifactorial, influenced by genetic, biological and environmental aspects. The aim of this study is to analyze the recent literature to verify the association between prenatal exposure to pesticides and the development of ASD in order to guide prevention and research actions. The present review article was developed from a bibliographic search carried out on the search portals PubMed, Virtual Health Library and Portal of Journals CAPES, with the selection of scientific articles published between the years 2016 and 2020. The analyzed literature points to evidence changes in gene expression due to environmental factors that can culminate in the development of ASD; however, the exact mechanisms are not yet known. In animals, exposure to pesticides can determine changes in neurodevelopment, although there is still no relationship between this finding and human behavior. Maternal proximity to regions with wide administration of pesticides during pregnancy has been associated with impaired cognition and verbal comprehension, increased risk for ASD and other intellectual deficits. Some substances can interfere as a protective factor or aggravating the association between the occurrence of ASD in view of pesticide exposure. In summary, the studies analyzed demonstrate the possible association between exposure to pesticides and the development of autism spectrum disorder, demonstrating that it is increasingly necessary to investigate the multifactorial etiopathogenesis of ASD.
How to Cite
Reis, I. L., Pinheiro, A. M. N., & Bachur, T. P. R. (2021). CAN PRENATAL EXPOSURE TO PESTICIDES UNLEASH THE AUTISTIC SPECTRUM DISORDER?, 14(2), 13-28. https://doi.org/10.22280/revintervol14ed2.497
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