USE OF LIPID EMULSION AS AN ANTIDOTE AGAINST CARDIOTOXICITY BY LIPID AGENTS OR MITOCHONDRIAL LIPID METABOLISM INHIBITORS

  • Tatiana Paschoalette Rodrigues Bachur Universidade Estadual do Ceará http://orcid.org/0000-0002-1975-9995
  • Anne Karoline Araújo Rocha Universidade Estadual do Ceará
  • Tiago de Sousa Viana Universidade Estadual do Ceará
  • Juliana Ciarlini Costa Universidade Estadual do Ceará

Abstract

Intravenous lipid emulsions (ELI) have been used for many years to provide parenteral nutritional support to hospitalized patients. However, recently, there has been growing interest in its role as a potential antidote for use in patients with severe cardiotoxicity caused by the toxic effect of different substances. In the current context, with increasing cases of attempted suicide by various medications, including cardiotoxic lipid drugs, the possibility of using ELI as an andidote becomes potentially relevant. The present work aimed to analyze the application of intravenous lipid emulsions as an antidote against drug-induced cardiotoxicity, and to understand the advances in this technique, as well as its efficacy and safety in its use for this purpose. For this proposal, a literature review was carried out, based on scientific articles published in the last five years, selected in the MEDLINE and LILACS databases, in the Google Academic electronic library and on websites of official institutions. Despite ongoing studies for the application of ELI as an antidote in drug-induced cardiotoxicity, the available literature is still insufficient to provide accurate information regarding the ideal dose, duration of treatment and adverse effects profile. Thus, we raised the discussion so that further studies can be carried out on this, which can be an important tool in the treatment of acute intoxications by lipid drugs that culminate in cardiotoxicity. Keywords: Intravenous Lipid Emulsion. Antidote. Cardiotoxicity.

Author Biographies

Tatiana Paschoalette Rodrigues Bachur, Universidade Estadual do Ceará
Docente da disciplina de Toxicologia Médica da Universidade Estadual do Ceará.
Anne Karoline Araújo Rocha, Universidade Estadual do Ceará
Acadêmica de Medicina
Tiago de Sousa Viana, Universidade Estadual do Ceará
Acadêmico de Medicina
Juliana Ciarlini Costa, Universidade Estadual do Ceará
Acadêmica de Medicina
Published
2020-06-23
How to Cite
Bachur, T. P. R., Rocha, A. K. A., Viana, T. de S., & Costa, J. C. (2020). USE OF LIPID EMULSION AS AN ANTIDOTE AGAINST CARDIOTOXICITY BY LIPID AGENTS OR MITOCHONDRIAL LIPID METABOLISM INHIBITORS, 13(2), 5-12. https://doi.org/10.22280/revintervol13ed2.472