HORMESIS, AGING AND TOXICITY: STATE OF ART

A NEW CONCEPT

  • André Rinaldi Fukushima Faculdade de Medicina Veterinária e Zootecnia - USP https://orcid.org/0000-0001-6026-3054
  • Sarah Cristina Gozzi e Silva Instituto de Medicina Tropical da Universidade de São Paulo Avenida Dr. Enéas Carvalho de Aguiar, 470 - CEP 05403-000 - SP/São Paulo - Brasil
  • Iago Portolani de Araujo Universidade São Judas Tadeu, Rua Taquari, 546 – Mooca São Paulo/SP, Brasil
  • Juliana Weckx Peña Muñoz Universidade São Judas Tadeu
  • Diana Madureira dos Santos Universidade São Judas Tadeu

Abstract

Aging is a natural and progressive process, which affects aspects of the individual holistically. An organism aged under normal conditions may survive adequately. However, when subjected to toxicological, physical and emotional stress, among others, it may present difficulties in maintaining its homeostasis and leading to the onset of the hormone mechanism. Hormese is derived from the Greek "hormaein" which means "to excite". In its first definition was described as a biphasic behavior, that is, a biological ability that can be modified by low doses of a xenobiotic, but inhibited by high doses of it, it was proposed as an explanation for changes in homeostasis. One of the most well-accepted theories related to aging is free radical theory. In addition to free radicals other xenobiotics may be intrinsically correlated with senescence of nerve cells, such as drugs of abuse, medications of continuous use, toxins and drugs, among others. This article intends to scientifically present a systematic literature review, bringing the themes hormone, aging and toxicology correlated to the areas of health, toxicology and regulation, showing the fundamental misunderstanding in nature when evaluating responses only by observing the triad dose x response x exposure . During the first decades of the twentieth century this error was the result of multiple factors, including the conflict between homeopathy and traditional medicine, and the evaluations of the hormone dose responses are difficult to interpret, requiring more attention and abstraction compared to linear models , traditionally accepted by the majority of the scientific community. The concept of hormone helps researchers to better address the low dose response, showing that there is adaptability of the organisms and can open a new look on the onset of chronic degenerative diseases and generating paradigm breaks in this perspective. Keywords: Aging. Hormese. Toxicity.

Author Biography

André Rinaldi Fukushima, Faculdade de Medicina Veterinária e Zootecnia - USP
Possui graduação em Farmácia pela Universidade São Judas Tadeu (2008). Mestrado em Toxicologia e Análises Toxicológicas pela Universidade de São Paulo (2010) e Doutorado em Toxicologia pelo departamento de Patologia Animal da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo. Foi professor, ministrando a disciplina de Química farmacêutica na Universidade Guarulhos (2010 - 2014). Foi por 8 anos e meio Professor na Universidade São Judas Tadeu nos cursos de farmácia, nutrição, biologia, enfermagem, biomedicina e medicina veterinária. Ministra aulas como professor convidado em duas pós graduações. Tem experiência na área de Toxicologia, com ênfase em Análises Toxicológicas, atuando principalmente nos seguintes temas: drogas de abuso, crack,cocaína, cocaetileno, toxicologia, toxicologia forense, toxicologia dos praguicidas, praguicidas, anticolinesterásicos. Mais recentemente assumiu o cargo de coordenador da pós-graduação em Saúde Coletiva na Universidade São Judas Tadeu - SP, sendo essa a primeira Pós-graduação em Saúde Coletiva ofertada por Universidade Particular pelo periodo de 1 ano. Coordena a área regulação com foco no ENADE no Centro Universitário das Américas (FAM) e é Coordenador de Pesquisa e Extensão na Faculdade de Ciências da Saúde IGESP (FASIG).
Published
2020-02-28
How to Cite
Fukushima, A. R., Silva, S. C. G. e, Araujo, I. P. de, Muñoz, J. W. P., & Santos, D. M. dos. (2020). HORMESIS, AGING AND TOXICITY: STATE OF ART , 13(1), 04-12. https://doi.org/10.22280/revintervol13ed1.454