HORMESIS, AGING AND TOXICITY: STATE OF ART
A NEW CONCEPT
AbstractAging is a natural and progressive process, which affects aspects of the individual holistically. An organism aged under normal conditions may survive adequately. However, when subjected to toxicological, physical and emotional stress, among others, it may present difficulties in maintaining its homeostasis and leading to the onset of the hormone mechanism. Hormese is derived from the Greek "hormaein" which means "to excite". In its first definition was described as a biphasic behavior, that is, a biological ability that can be modified by low doses of a xenobiotic, but inhibited by high doses of it, it was proposed as an explanation for changes in homeostasis. One of the most well-accepted theories related to aging is free radical theory. In addition to free radicals other xenobiotics may be intrinsically correlated with senescence of nerve cells, such as drugs of abuse, medications of continuous use, toxins and drugs, among others. This article intends to scientifically present a systematic literature review, bringing the themes hormone, aging and toxicology correlated to the areas of health, toxicology and regulation, showing the fundamental misunderstanding in nature when evaluating responses only by observing the triad dose x response x exposure . During the first decades of the twentieth century this error was the result of multiple factors, including the conflict between homeopathy and traditional medicine, and the evaluations of the hormone dose responses are difficult to interpret, requiring more attention and abstraction compared to linear models , traditionally accepted by the majority of the scientific community. The concept of hormone helps researchers to better address the low dose response, showing that there is adaptability of the organisms and can open a new look on the onset of chronic degenerative diseases and generating paradigm breaks in this perspective. Keywords: Aging. Hormese. Toxicity.
How to Cite
Fukushima, A. R., Silva, S. C. G. e, Araujo, I. P. de, Muñoz, J. W. P., & Santos, D. M. dos. (2020). HORMESIS, AGING AND TOXICITY: STATE OF ART , 13(1), 04-12. https://doi.org/10.22280/revintervol13ed1.454
FARMÁCIA (ANÁLISE TOXICOLÓGICA)
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